microRNA ID

log 2FC

P value

Description in previous studies

Up-regulated genes

mir-494 3p

3.5153

7.64E−11

Inhibits proliferation of MC3T3E1 cells [22] ; inhibits proliferation and metastasis of osteosarcoma [23] ; induces cellular senescence of oral squamous carcinoma cells [24] .

mir-466

2.9299

1.08E−10

Inhibits tumour growth and bone metastasis in prostate cancer [25] ; inhibits lymph angiogenesis [26]

mir-455

2.4634

3.25E−23

Shows increased expression in the course of chondrogenesis and OA cartilage [27] ; a tumour suppressor [28] .

mir-708

1.6471

0.0006

Promotes steroid-induced osteonecrosis of femoral head and suppresses osteogenic differentiation [29]

Down-regulated genes

mir-298

2.7127

2.85E−08

Counteracts mutant androgen receptor toxicity in spinal and bulbar muscular atrophy [30] ; raises the propensity to apoptosis of αTC1-6 cells [31] .

mir-92

1.5842

8.56E−06

promotes growth and metastasis of cancer cells [32] ; deletion of miR-92a is sufficient to induce a developmental skeletal defect [33] ; has potential to be a biomarker of osteogenesis imperfecta [34] ;

mir-224

1.1107

5.23E−06

Suppresses osteosarcoma cell proliferation, migration and invasion [35] ; promotes the metastasis of breast cancer cells [36] .