microRNA ID | log 2FC | P value | Description in previous studies |
Up-regulated genes | |||
mir-494 3p | 3.5153 | 7.64E−11 | Inhibits proliferation of MC3T3E1 cells [22] ; inhibits proliferation and metastasis of osteosarcoma [23] ; induces cellular senescence of oral squamous carcinoma cells [24] . |
mir-466 | 2.9299 | 1.08E−10 | Inhibits tumour growth and bone metastasis in prostate cancer [25] ; inhibits lymph angiogenesis [26] |
mir-455 | 2.4634 | 3.25E−23 | Shows increased expression in the course of chondrogenesis and OA cartilage [27] ; a tumour suppressor [28] . |
mir-708 | 1.6471 | 0.0006 | Promotes steroid-induced osteonecrosis of femoral head and suppresses osteogenic differentiation [29] |
Down-regulated genes | |||
mir-298 | 2.7127 | 2.85E−08 | Counteracts mutant androgen receptor toxicity in spinal and bulbar muscular atrophy [30] ; raises the propensity to apoptosis of αTC1-6 cells [31] . |
mir-92 | 1.5842 | 8.56E−06 | promotes growth and metastasis of cancer cells [32] ; deletion of miR-92a is sufficient to induce a developmental skeletal defect [33] ; has potential to be a biomarker of osteogenesis imperfecta [34] ; |
mir-224 | 1.1107 | 5.23E−06 | Suppresses osteosarcoma cell proliferation, migration and invasion [35] ; promotes the metastasis of breast cancer cells [36] . |