| Recurrent VTE | Serious or fatal bleeding | Both recurrent VTE and severe bleeding |
| Initial unprovoked VTE | Low platelet count | Increased age |
| Initial proximal DVT or PE | Previous bleeding | Cancer |
| Thrombophilia | Recent major bleeding | Immobilization |
| Residual proximal thrombosis | Previous stroke | Recent surgery (transient) |
| Male sex | Hepatic failure | Severe renal impairment |
| Elevated D-dimer concentrations | Diabetes |
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| When not receiving anticoagulation | Abnormal prothrombin time |
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| Pregnancy | Thrombocytopenia |
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| Anticoagulation lasting < 3 months | Poor anticoagulant control |
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| Comorbidity |
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| Anemia |
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