Mean (SD)

Median (Range)

OH

OL

TA

TAS

p-value

Subjective comfort

80.7 (17.2)

80.0 (20 to 100)

86.0 (16.0)

90.0 (20 to 100)

59.4 (22.9)

60.0 (5 to 100)

73.5 (21.6)

70.0 (20 to 100)

<0.001

OH-TA < 0.001

OH-TAS 0.027

OL-TA < 0.001

OL-TAS < 0.001

Ocular redness

0.4 (0.5)

0.0 (0 to 1)

0.3 (0.5)

0.0 (0 to 1)

0.4 (0.5)

0.0 (0 to 2)

0.3 (0.5)

0.0 (0 to 1)

0.354

Bulbar and nasal conjunctival redness

1.2 (0.5)

1.1 (0.0 to 2.2)

1.2 (0.5)

1.1 (0.2 to 2.2)

1.3 (0.6)

1.3 (0.0 to 2.5)

1.3 (0.5)

1.2 (0.3 to 2.3)

0.267

TBUT 1st measurement

(seconds)

9.5 (6.6)

8.2 (1.7 to 25.0)

8.9 (5.5)

8.4 (1.2 to 24.0)

6.3 (5.2)

4.5 (0.8 to 24.0)

7.1 (5.8)

4.8 (1.2 to 25.0)

<0.001

OH-TA < 0.001

OH-TAS 0.004

OL-TA < 0.001

OL-TAS 0.002

TBUT average

(seconds)

13.3 (5.7)

12.2 (2.5 to 25.0)

12.3 (5.2)

11.2 (2.5 to 24.0)

9.4 (5.5)

8.6 (2.0 to 24.0)

10.2 (5.9)

10.9 (2.4 to 25.0)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS 0.002

Smell

0.1 (0.4)

0.0 (0 to 2)

0.1 (0.5)

0.0 (0 to 2)

2.6 (1.6)

3.0 (0 to 5)

2.0 (1.5)

2.0 (0 to 5)

<0.001

OH-TA < 0.001

OH-TAS < 0.001

OL-TA < 0.001

OL-TAS < 0.001

Application comfort

0.8 (6.5)

0.0 (0 to 60)

0.6 (5.6)

0.0 (0 to 50)

6.9 (15.4)

0.0 (0 to 60)

0.8 (3.5)

0.0 (0 to 20)

<0.001

OH-TA < 0.001

OH-TAS 0.241

OL-TA < 0.001

OL-TAS 0.119