Gene target | Gene accession no. | CPP-PNA sequence sequencea | Proposed functions/Drug |
inhA | MSMEG_3151 | H-KFFKFFKFFK-O-gtcatttggt-NH2 | Isoniazid Enoyl-ACP reductase (acyl carrier protein) of fatty acid synthase II needed to elongate long chain fatty acids for the synthesis of mycolic acid/Isoniazid (INH) |
rpsL | MSMEG_1398 | H-KFFKFFKFFK-O-ttggcatgta-NH2 | Ribosomal protein S12/Streptomycin |
gyrA | MSMEG_0456 | H-KFFKFFKFFK-O-catatcgtcgga-NH2 | DNA gyrase subunit A/Fluoroquinolones |
pncA | MSMEG_6506 | H-KFFKFFKFFK-O-catgcctcga-NH2 | PZA inhibits the activity of FAS I (palmitic acid) in PZA-susceptible M. smegmatis strains/Pyrazinamide (PZA) |
polA | MSMEG_3839 | H-KFFKFFKFFK-O-ttcatgcctgt-NH2 | DNA polymerase I |
rpoC | MSMEG_1368 | H-KFFKFFKFFK-O-catcgtaactc-NH2 | RNA polymerase subunit β |
dnaG (negative control PNA) | BR_1480 | H-KFFKFFKFFK-O-cattacagatt-NH2 | Mismatch PNA for DNA primase |