Gene target

Gene accession no.

CPP-PNA sequence sequence^a

Proposed functions/Drug

inhA

MSMEG_3151

H-KFFKFFKFFK-O-gtcatttggt-NH₂

Isoniazid Enoyl-ACP reductase (acyl carrier protein) of fatty acid synthase II needed to elongate long chain fatty acids for the synthesis of mycolic acid/Isoniazid (INH)

rpsL

MSMEG_1398

H-KFFKFFKFFK-O-ttggcatgta-NH₂

Ribosomal protein S12/Streptomycin

gyrA

MSMEG_0456

H-KFFKFFKFFK-O-catatcgtcgga-NH₂

DNA gyrase subunit A/Fluoroquinolones

pncA

MSMEG_6506

H-KFFKFFKFFK-O-catgcctcga-NH₂

PZA inhibits the activity of FAS I (palmitic acid) in PZA-susceptible M. smegmatis strains/Pyrazinamide (PZA)

polA

MSMEG_3839

H-KFFKFFKFFK-O-ttcatgcctgt-NH₂

DNA polymerase I

rpoC

MSMEG_1368

H-KFFKFFKFFK-O-catcgtaactc-NH₂

RNA polymerase subunit β

dnaG (negative control PNA)

BR_1480

H-KFFKFFKFFK-O-cattacagatt-NH₂

Mismatch PNA for DNA primase