Trials

Sample

Size (n)

Centre

Key Inclusion Criteria

Follow-up

(Months)

Primary Endpoint

CTO-IVUS 2015 [35]

201

Multi-centre

CTO

12

Cardiac death: 0% versus 1%, p = 0.16

Tan et al. 2015 [36]

61/62

Single centre

Unprotected LM

24

MACE: 13.1% versus 29.3%, p = 0.031

IVUS-XPL 2015 [5]

700

Multi-centre

Long lesions (stent length > 28 mm

12

MACE: 2.9% versus 5.8%, p = 0.007

Zhang et al. 2016 [37]

42

Single centre

Small vessel disease (2.25 - 2.75 mm)

12

Post-PCI MLD: 2.77 ± 0.46 mm versus 2.53 + 0.21 mm, p < 0.0001

ULTIMATE 2018 [4]

72

Multi-centre

All corners

12

TVF: 2.9% vs 5.4%, p = 0.019