Year	Source	N of included studies/patients	Regimen	3-day rebleeding risk	7-day rebleeding risk	Mortality
2010	Wang CH et al. High-dose vs. non-high-dose proton pump inhibitors after endoscopic treatment in patients with bleeding peptic ulcer: a systematic review and meta-analysis of randomized controlled trials [11] .	7 RCT including 1157 patients	80-mg bolus, followed by 8-mg/h continuous infusion for 72 hours. Continuous infusion doses exceeding 192 mg/d were also considered high-dose PPIs. Other doses were considered non-high-dose PPIs.	High-dose PPIs and non-high-dose PPIs did not differ in their effects on the rates of rebleeding OR, 1.30; 95% CI, 0.88 - 1.91.		No difference in mortality, OR 0.89; 95% CI 0.37 - 2.13.
2010	Wu LC et al. High-dose vs. low-dose proton pump inhibitors for upper gastrointestinal bleeding: a meta-analysis. World J Gastroenterol [12] .	9 RCTs, including 1342 patients, were included in the analysis.	The dosage of PPI was considered a high dose if at least twice the low dose of any PPIs was used during the 72 hours following endoscopic hemostasis.	A high-dose PPI regimen is not superior to a low-dose PPI regimen.		A high-dose PPI regimen is not superior to a low-dose PPI regimen.
2013	Neumann I et al. Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev [14] .	13 RCTs (1716 patients)	“High” dose regimens are considered 72-hour cumulative doses > 600 mg of intravenous PPI compared to other doses.	Insufficient evidence for concluding results		insufficient evidence for concluding results
2014	Sachar H et al. Intermittent vs. continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis [15] .	13 studies included in meta-analysis	80-mg intravenous bolus followed by a continuous 8-mg/h intravenous infusion for 72 hours vs boluses (they could be once daily or more often; oral vs intravenous).	Intermittent PPI regimen is comparable to bolus plus continuous infusions RR < 1	RR for intermittent vs. bolus plus continuous infusion of PPIs was 0.72	RR for mortality < 1
2018	Sgourakis G et al. A meta-analysis and meta-regression analysis. Turk J Gastroenterol [16] .	10 RCTs included 1.651 patients.	A high-dose PPI regimen is identified as an 80 mg bolus followed by intravenous administration of 8 mg/h for 72 h; a low-dose regimen is not specified.	Significantly fewer cases of rebleeding in the low-dose PPI treatment arm		comparable outcomes.