Single item PAC-QoL

Comparison versus Placebo

Odds ratio

(95% confidence interval)

p-value

1: Have you felt bloated to the point of bursting?

3.412

(2.517, 4.624)

<0.0001

2: Have you felt heavy because of your constipation?

5.931

(4.312, 8.160)

<0.0001

3: Have you felt any physical discomfort?

2.576

(1.910, 3.474)

<0.0001

4: Have you felt the need to open your bowel but not been able to?

5.157

(3.776, 7.043)

<0.0001

5: Have you been embarrassed to be with other people?

1.563

(1.134, 2.156)

0.0064

6: Have you been eating less and less because of not being able to have bowel movements?

3.023

(2.200, 4.155)

<0.0001

7: Have you had to be careful about what you eat?

2.545

(1.874 , 3.456)

<0.0001

8: Have you had a decreased appetite?

1.875

(1.361, 2.583)

0.0001

9: Have you been worried about not being able to choose what you eat (for example, at friend’s)?

2.365

(1.689, 3.313)

<0.0001

10: Have you been embarrassed about staying in the toilet for so long when you were away from home?

1.434

(1.067, 1.928)

0.0170

11: Have you been embarrassed about having to go to the toilet so often when you were away from home?

0.837

(0.622, 1.127)

0.2407

12: Have you been worried about having to change your daily routine (for example, travelling, being away from home)?

0.894

(0.665, 1.203)

0.4599

13: Have you felt irritable because of your condition?

3.004

(2.207, 4.088)

<.0001

14: Have you been upset by your condition?

3.413

(2.501, 4.656)

<0.0001

15: Have you felt obsessed by your condition?

2.148

(1.576, 2.927)

<0.0001

16: Have you felt stressed by your condition?

2.405

(1.775, 3.257)

<0.0001

17: Have you been less self−confident because of your condition?

1.671

(1.223, 2.282)

0.0012

18: Have you felt in control of your situation?

1.650

(1.236, 2.203

0.0007

19: Have you been worried about not knowing when you are going to be able to open your bowels?

1.783

(1.328, 2.394)

0.0001

20: Have you been worried about not being able to open your bowels when you needed to?

3.615

(2.663, 4.908)

<0.0001

21: Have you been more and more bothered by not being able to open your bowels?

3.845

(2.819, 5.244)

<0.0001

22: Have you been afraid that your condition will get worse?

3.314

(2.422, 4.535)

<0.0001

23: Have you felt that your body was not working properly?

3.214

(2.377, 4.344)

<0.0001

24: Have you had fewer bowel movements than you would like?

7.566

(5.468, 10.470)

<0.0001

25: Have you been satisfied with how often you open your bowels?

7.336

(5.319, 10.118)

<0.0001

26: Have you been satisfied with the regularity with which you open your bowels?

6.160

(4.508, 8.418)

<0.0001

27: Have you been satisfied with your bowel function?

6.711

(4.894 , 9.201)

<0.0001

28: Have you been satisfied with your treatment?

4.162

(4.508, 8.418)

<0.0001