Time

Group I

(n = 50)

Group II

(n = 50)

P-value

Effect size (d)

Median (Range)

Mean (SD)

Median (Range)

Mean (SD)

Pre-treatment

76 (76 - 84) ^A

77.6 (3.8)

86 (47 - 86) ^A

81.4 (9.2)

<0.001*

1.089

1 day

57 (57 - 83) ^B

62.1 (9.6)

34 (28 - 60) ^B

35.9 (6.4)

<0.001*

2.485

3 days

42 (42 - 68) ^C

47.2 (9.7)

17 (13 - 52) ^C

19.3 (7)

<0.001*

2.963

5 days

26 (26 - 61) ^D

32.9 (13.3)

17 (9 - 45) ^C

17.2 (4.3)

<0.001*

2.963

7 days

29 (16 - 56) ^D

33.6 (10.6)

17 (9 - 44) ^C

16.8 (4.5)

<0.001*

2.591

After healing

30 (16 - 54) ^D

32.9 (9.5)

17 (9 - 17) ^C

16.3 (1.8)

<0.001*

2.52

P-value

<0.001*

<0.001*

Effect size (w)

0.916

0.948