Aloe vera

Increases type III collagen synthesis.

Induces the synthesis of hyaluronic acid.

Induces granulation tissue formation in the remodeling phase

Increases wound contraction.

Increases macrophage activation markers.

Stimulates fibroblasts and collagen synthesis.

Regulates the expression of MMP-3 and TIMP-2 in the granulation tissue.

Ali F

Sánchez M

Sari Y

Jamil M

Tanaka M,

Hashemi SA

Tabandeh MR,

Budai

Babaee N

Davis RH

2021

2020

2018

2018

2015

2015

2014

2013

2012

1989

[251]

[252]

[217]

[253]

[254]

[255]

[256]

[257]

[258]

[250]

Scrophularia striata

Decreases the wound area and lymphocytes number,

Enhanced the number of fibroblasts at the earlier stages

Increased the number of fibrocytes at the later stages of wound healing.

Alignment of the healing tissue, re-epithelilization and epithelial formation,

Enhancement of the maturity of the collagen fibers and fibroblasts and large capillary-sized blood vessels

Chatzopoulos GS

Kerdar T

Haddadi R

Ghashghaii A

Tanideh N

2022

2019

2019

2017

2015

[260]

[261]

[262]

[263]

[259]

Alternanthera sessilis

Enhancement of cell migration

Muniandy K,

Enechi OC

Jalalpure SS

2018

2013

2008

[265]

[266]

[264]

Euphorbiaceae species

Acceleration of the wound healing process and wound contraction.

Ahmed S,

2016

[267]

Abelmoschus esculentus

Okra

Increases angiogenesis during the wound healing process in oral cavity

Luthfi M,

2020

[269]

Amla/

Emblic myrobalan

Bilberry fruit/Vaccinium myrtillus

Hawthorn berry/Crateagus oxycanthus

Liquorice root/Glycyrrhiza glabral

Neem extract

Mango leaf

The miswak/Miswaak, siwak, sewak

Sesame oil

Yellow dock root,

Alfalfa leaf,

Cinnamon bark,

Turmeric root.

Benefic effects on gingivitis

Antibacterial effect

Collagen stabilization

Singh A,

2011

[268]

Roots of Albizzia lebbeck

Antibacterial properties

Enhancement of collagen synthesis

Antioxidant activity.

Acute oral toxicity

Joshi A,

2013

[270]