Camellia sinensis

Significant reduction in premature senescence after Local EGCG and systemic senolytic administration in bone defects

Enhancement in osteogenesis by periodontal ligament cells

Enhancement in anti-inflammatory and bone healing activity

Enhancement in healing process, cell proliferation and attachment

Inhibition of osteoblast migration

Diminution of osteoclastic activity through its anti-oxidant property

Improvement in healing process

Increases osteogenic markers, proliferation and mineralization

Increases cell proliferation

Anti-oxidant properties thus increase periosteal cell viability for a short-term period

Maximum bone regeneration in combination of tricalcium phosphate particles

Chu C,

Xie Y,

Soares IMV,

Honda Y,

Kawabata T,

Katsumata Y,

Kuroyanagi G,

Hong JY,

Kaida K,

Mah YJ,

Kamiya M,

2019

2018

2017

2015

2014

2012

[147]

[161]

[146]

[191]

[192]

[193]

[194]

[195]

[196]

[197]

[198]

Curcuma longa/ Curcumin

Enhancement in osteoblastic cell viability and proliferation

Mineralized bone formation increased

Enhancement of osteoblastic cell viability

Improvement in cell migration and differentiation

Improvement in bone formation

Enhancement in ALP expression and mineral deposition

Sarkar N,

Bose S,

Li Y,

Jain S,

2019

2018

2016

[149]

[150]

[151]

[148]

Coffea arabica

Chlorogenic acid

Significant anti-bacterial property against K. pneumonia and S. aureus

Enhancement of chondrogenesis, cartilage matrix synthesis and angiogenesis

Enhancement in levels of bone turnover markers and cellular osteogenic differentiation

Palaniraj S,

Cheng X,

Fujita K,

Zhou RP,

2019

2018

2017

2016

[153]

[154]

[155]

[152]

Coconut oil

periodontal tissue regeneration via expressions of tnf-α and tgf-β1

Thahir

2022

[159]