Rhizoma drynariae

Enhanced the proliferation of BM-derived hMSCs by regulating β-catenin and AMP-activated protein kinase (AMPK)

Alaribe F N,

Udalamaththa DL,

Zhang P,

2019

2016

2009

[104]

[103]

[120]

Foeniculum vulgare

Promotes the proliferation and differentiation of BM-derived hMSC into osteoblasts

Alaribe F N,

2019

[104]

Ferula gummosa

Antibacterial effect

Enhance proliferation and differentiation of BM-derived hMSCs into osteocytes.

Abbaszadegan A

2015

[105]

Resveratrol

Proliferation and differentiation roles of articular cartilage

High regulation of collagen type II has been observed chondrocytes treated with resveratrol

bone regenerative and anti-osteoporotic efficacy: Enhancement of entochondrostosis and osteogenic markers expression

Improvement in bone regeneration

bone-healing properties in periodontitis: Significant anti-inflammatory property and inhibition of bone loss

Significant increase in blood supply in necrotic area: Increase in expression of angiogenic factor

Stimulation of osteoblastic differentiation in presence of inflammation

Induces higher expression of BMPs and improves bone regeneration

Alaribe F N,

Wang CC,

Ozcan-Kucuk A

Ikeda E,

Mmadira MG,

Zhai JL,

Rutledge KE,

Ornstrup MJ,

Wang W,

Kamath MS,

Casarin RC,

Lee AM,

2019

2018

2016

2014

[104]

[178]

[106]

[111]

[108]

[179]

[180]

[181]

[182]

[183]

[107]

[184]

RUTTIN/

MORINDA citrifolia extract

Induction of osteogenic differentiation in human periodontal ligament cells

Regulation of bone formation, improvement of chondrocytes cellularity

Induction of cellular proliferation and matrix formation

Enhancement of matrix mineralization

Improvement in bone mechanical and physical properties/ Enhancement in osteogenic biomarkers expression

Increases bone density

Zhao B,

Min SK,

Wan Osman WN,

Zhao B,

Gu H,

Shalan NA,

Hussain S

2020

2019

2018

2017

2016

[92]

[174]

[175]

[185]

[186]

[176]

[187]

[188]

[189]

Fructus Ligustri Lucidi

Increases ALP activity,

Increases the expression of osteogenesis-stimulating genes, osteoprotegerin

Ko. C

Li. G

2010

2009

[113]

[112]

Cnidium monnieri/

Angelica pubescens

Osthole

Induction of osteoclastogenesis: Enhancement in osteogenic activity

Enhancement of bone healing and formation

Enhancement of bone strength and fracture healing by through BMP2 signaling pathway

Enhancement in bone formation rate, ALP activity, OCN and BMP2 expression

Zhao D,

Zhang ZR,

Sun J,

Wang P,

Zhang Z,

Gao LN,

2018

2017

2016

2013

[190]

[115]

[116]

[117]

[118]

[114]

China Herba epimedii

Increases ALP activity and enhances mRNA expression of BMP-2, Runx2 (runt-related transcription factor 2), and OPN (osteopontin)

Zhang JF

2009

[119]