Medicinal plant	Effect	Author	Year	Ref
Galla chinensis	Anticariogenic contains metabolites, such as tannins and flavonoids Promotes mineral apposition in cavity lesions	Zhang J Kumar Zhang J Cheng,	2022 2022 2015 2010	[24] [25] [26] [23]
Carboxymethyl chitosan	Anticariogenic Some natural toothpastes use present in the exoskeleton of crustaceans	Cicciù, M	2019	[28]
Ilex guayusa	Anticariogenic, enamel remineralization Used by indigenous and rural communities for the treatment of oral cavity diseases Mouthwash, herbal tea and energizing drink, among others Phytochemically it contains caffeine, triterpenes, chlorogenic acids, tannins, and flavonoids	Gutiérrez, Bernal Sequeda-Castañeda,	2022 2011 2016	[29] [30] [27]
Piper marginatum	Antifungal Commonly known as “tooth healer,” its leaves topically applied against tooth cavities Phytochemical studies demonstrate the presence of steroids, alkaloids, flavonoids, phenolic compounds, phenylpropanoids and terpenoids, among others. Cytotoxic in vivo study on rats	Gutiérrez, Gonçalves Sequeda-Castañeda Brú & Guzman, Reigada	2022 2019 2016 2016 2007	[29] [32] [27] [33] [31]
Perilla frutescens seed	Prevents dental caries, antibacterial ↑Remineralization of enamel caries lesions, volume & mineral density values, ↓Severity of molar enamel caries Contains various polyphenols such as luteolin, quercetin, gallic acid, and epigallocatechin gallate	Zhang J, Yamamoto H	2015 2002	[26] [34]
Coconut extracts	Coconut milk and coconut water are potentially capable for enamel remineralization.	Rahamat F	2019	[35] [36]