|
| A.A [Nucleotide] |
|
| Mutant frequency % (n) per year |
| |||
| Codon | Nucleotide | Wild type | Mutant | Type | N/S | 2016/2017 | 2018 | P-value |
| 62 | 185 | S [G] | N [A]* | Trans | N | 42.8 (28) | 50 (14) | 1 × 10−34 |
| 65 | 193 | K [A] | Q [C]* | Transv | N | 28.5 (28) | 57.1 (28) | 2.5 × 10−76 |
| 67 | 200 | E [A] | G [G]* | Sub | N | 35.7 (28) | 57.1 (28) | 7 × 10−40 |
| 67 | 201 | E [A] | G [T]* | Sub | N | 35.7 (28) | 50 (28) | 7 × 10−40 |
| 120 | 359 | S [G] | I [T]* | Transv | N | 23 (26) | 23 (26) | 1 × 10−10 |
| 130 | 390 | E [G] | D [C]* | Transv | N | 7.8 (26) | 15.38 (26) | 3.3 × 10−9 |
| 146 | 437 | R [G] | K [A] | Trans | N | 45.4 (22) | 36.3 (22) | 2 × 10−13 |
| 150 | 448 | D [G] | N [A] | Trans | N | 45.4 (22) | 54.5 (22) | 1.6 × 10−20 |
| 155 | 463 | T [A] | P [C] | Transv | N | 45.4 (22) | 54.5 (22) | 6.3 × 10−14 |
| 160 | 479 | R [G] | K [A] | Trans | N | 45.4 (22) | 54.5 (22) | 4 × 10−16 |
| 163 | 487 | D [G] | N [A] | Trans | N | 45.4 (22) | 54.5 (22) | 3.2 × 10−17 |
| 164 | 492 | K [G] | K [A] | Trans | S | 45.4 (22) | 54.5 (22) | 4 × 10−16 |
| 179 | 536 | R [G] | K [A] | Trans | N | 45.4 (22) | 45.4 (22) | 10−14 |
| 188 | 562 | E [G] | K [A] | Trans | N | 36.3 (22) | 45.4 (22) | 4 × 10−16 |
| 194 | 582 | A [A] | A [C] | Transv | S | 27.2 (22) | 45.4 (22) | 5.7 × 10−9 |
| 195 | 584 | R [G] | Q [A] | Trans | N | 45.4 (22) | 54.5 (22) | 2.5 × 10−7 |
| 238 | 714 | K [G] | K [A] | Trans | S | 50 (20) | 30 (20) | 6.8 × 10−12 |
| 271 | 811 | D [G] | N [A] | Trans | N | 33.3 (18) | 33.3 (18) | 5 × 10−9 |
| 148 | 443 | Y [A] | F [T] | Transv | N | 18.18 (22) | 18.18 (22) |
|
| 203 | 609 | N [T] | K (G] | Transv | N | 9 (22) | 9 (22) |
|
| 229 | 687 | T [A] | T [C] | Transv | S | 0 (20) | 10 (20) |
|
| 279 | 835 | D [G] | H [C] | Transv | N | 11.11 (16) | 0 (16) |
|
| 305 | 914 | Q [A] | L [T] | Transv | N | 20 (10) | 0 (10) |
|
| 306 | 916 | D [G] | N [A] | Trans | N | 20 (10) | 20 (10) |
|