Reference	Title	Infections & Immune Status	Follow up results
Carter MT et al. [3]	Phenotypic delineation of Emanuel syndrome (supernumerary derivative 22 syndrome): Clinical features of 63 individuals.	Recurrent ear infections were seen in 96%; 19% had low immunoglobulins and 9% were treated with IVIG which had reported benefit.	no conclusions can be drawn about the use of IVIG.
Emanuel BS et al. [4]	Abnormal chromosome 22 and recurrence of trisomy-22 syndrome.	Recurrent pneumonia developed in nearly 47% of affected patients.	No mention about results
Kapoor S [6]	Emanuel syndrome: A rare disorder that is often confused with Kabuki syndrome.	Cryptorchidism was seen in 46% of ES patients while recurrent urinary tract infections were seen in 18% of affected individuals.	No mention about results
Tovo et al. [7]	Thymic hormone dependent immunodeficiency in an infant with partial trisomy of chromosome 22.	Decreased immunoglobulin levels were found in affected patients.	Thymostimulin increased IgG levels.
Our case	Efficacy of intravenous immunoglobulin in a case of Emanuel syndrome	The level of IgG was below the normal range for his age and recurrent seizures occurred.	Decreased the frequency of infections and seizures after IVIG therapy.