1) Magnitude

Magnitude of the problem; in terms of the proportion of the population, such as women, under 5 children, elderly, are affected.


2) Severity

Of the condition; i.e. danger to the individual and the community. How serious is the condition. Does it threaten life, cause major suffering, and decrease the ability to lead a normal life.


3) Effectiveness

Based on the best existing evidence and knowledge, would intervention be efficacious in reducing disease burden? It is likely to be effective under programme conditions


4) Feasibility

Taking into account a) the infrastructure and resources required to deliver effective interventions (e.g. human resources, health facilities, communication and transport infrastructure), and b) the need for change in demand, beliefs and attitudes of users, would you say that the endpoints of the research would be deliverable? affordability and sustainability


5) Burden

Diseases burden reduction; taking into account the best available information, would you say that reaching of research endpoints would eventually, have a “capacity” to impact directly and indirectly disease burden. E.g. up to 5% to 10% reduction in long run.


6) Equity

Equity enhancing; does the intervention affect mainly the underprivileged in the population? Intervention has potential to improve equity in disease burden distribution in the longer term?