Patient No. | Clinical Presentation | Radiological findings |
1 | APL variant revealed by: Fever Weight loss(1 month or more) Cough Hemoptysis Respiratory distress Incubated 7 transferred to ICU | Chest X-ray and US abdomen at admission: Normal CT scan at decompensation: Mediastinal LN, pericardial, pleural effusion, ascites, Hepato-splenomegaly with hypodense lesions peritoneal involvement. |
2 | APL variant revealed by: fever with unknown origin, persistence of fever during induction phase and after neutropenia recovery | Chest X-ray and US abdomen at admission: Normal CT scan after neutropenia recovery: left lower lobe basal fibrotic atelectasis band, mediastinal and right hilar lymphadenopathy with central necrosis |
3 | APL hypergranular subtype revealed by: Fever of unknown origin for 3 months Abdominal pain Anorexia Weight loss | Chest X-ray and US abdomen at admission: normal CT scan after 1 week of APL treatment: mediastinal lymph nodes and bilateral lung infiltrate suggestive of pulmonary edema 2nd CT scan after neutropenia recovery: Increase of mediastinal lymph nodes size and hepatic hypodense lesions MRI abdomen: suggestive of liver abscess 3rd CT scan and MRI during maintenance therapy: mediastinal LN, minimal pleural effusion, hepatic abscess, peritoneal thickening and nodules, ascites, mesenteric and omental nodularity PET CT scan: FDG avid uptake involving the whole abdomen with absence of uptake in mediastinal LN |
4 | AML/MDS on palliative treatment: fever Productive cough Weight loss Night sweat for 2 weeks | ・ Chest X-ray: lung consolidation in the right upper and mid lung zones ・ CT-Scan: Consolidation ・ PET CT-Scan: bilateral lung consolidations and peri-bronchial thickening, hilar and mesenteric LNs |
5 | AML with t(8,21) revealed by Fever Productive cough Weight loss and anemia symptoms for 2 months | ・ Chest X-ray at admission: Normal ・ CT-scan at admission; right and basal lung consolidation, multiple lung nodules, mediastinal and intraperitoneal lymph nodes some of them with central necrosis, hepato-splengomy with hypo-dense lesion ・ PET-CT scan: multiple mediastinal LNs, left lung consolidation, pulmonary nodules, retroperitoneal LN, multiple liver lesions, left parotid gland uptake and D8 vertebra uptake |
6 | AML with normal cytogenetic revealed by: Fever productive cough weight loss generalized LN for 2 months | ・ Chest X-ray at admission: normal ・ CT-Scan at admission: ground glass appearance in both lungs, associated with pulmonary nodules, generalized LN some of them with central necrosis |