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Experimental conditions

Cell type used

Tissue derived

Reference

1

All-trans retinoic acid

hESCs

Smooth muscle cells

Huang et al., 2006

2

Co-culture with fetal liver stromal cells

hESCs

Functional erythrocytes

Ma et al., 2008

3

Transient reactivation of c-Myc after reprogramming

Human dermal fibroblast derived hiPSCs

Megakaryocytes and Platelets

Takayama et al., 2010

4

Sequential treatment with activin A + BMP4 + FGF2 + HGF

Fibroblast derived hiPSC

Hepatocyte-like cells

Si-Tayeb K et al, 2010

5

Mouse ESCs treatment with various concentrations of Simvastatin

Osteogenic Progenitors

Successful osteogenic differentiation

Pagkalos et al., 2010

6

Pro-intestinal culture + activin + Wnt3A+ FGF4

hiPSCs and hESCs

Intestinal tissue

Spence et al., 2011

7

Feeder free + FGF inhibitor: SU5402, MEK inhibitor: PD184352, and GSK3 inhibitor: CHIR99021)

Rat ESCs

Cardiomyocytes

Cao et al., 2011

8

Matrix sandwich + sequential treatment with Activin A, BMP4, & bFGF

Foreskin fibroblast derived hiPSCs

Cardiomyocytes

Zhang J et al., 2012

9

Activin + (SB431542+ Noggin) + (EGF + FGF10 + KGF + Wnt3a)

Fibroblast derived hiPSC

Alveolar type I and II cells

Ghaedi M et al., 2013

10

Wnt pathway activator, CHIR99021, and either AM580 or TTNPB

hiPSCs/hESCs

Kidney lineage cells

Araoka et al., 2014

11

Retinoic acid and BMP4 treatment and culture on Collagen-I & IV dishes

hiPSC

keratinocytes

Kogut et al., 2014

12

High (60%) Oxygen culture conditions

Mouse ESCs and hiPSCs

Endocrine progenitors (Insulin producing)

Hakim et al., 2014