Variable

Number

Bivariate hazard

Ratio (95% CI)

p

Multivariable hazard

Ratio (95% CI)

p

Female

Male

86

147

1.13 (0.79 - 1.63)

0.47

Age < 70 years

Age ≥ 70 years

147

86

0.34 (0.24 - 0.48)

<0.001

0.44 (0.30 - 0.65)

<0.001

No Previous CRC

Previous CRC

228

5

0.61 (0.19 - 1.93)

0.40

No Resection at urgent operation

Resection at urgent operation

230

3

0.44 (0.11 - 1.77)

0.25

No Venous invasion

Venous invasion

181

52

0.70 (0.48 - 1.04)

0.08

No lymphatic vessel invasion

Lymphatic vessel invasion

156

77

0.49 (0.34 - 0.69)

<0.001

0.47 (0.32 - 0.68)

<0.001

No positive margin

Positive margin

212

21

0.16 (0.10 - 0.26)

<0.001

0.23 (0.14 - 0.39)

<0.001

Adenocarcinoma

Mucinous adenoCa/ Signet ring

208

25

0.68 (0.41 - 1.13)

0.14

Neoadjuvant radiotherapy

No neoadjuvant radiotherapy

50

183

1.19 (0.78 - 1.80)

0.41

Neoadjuvant chemotherapy

No neoadjuvant chemotherapy

32

201

1.07 (0.64 - 1.78)

0.79

Adjuvant radiotherapy

No adjuvant radiotherapy

14

219

1.40 (0.73 - 2.67)

0.31

Adjuvant chemotherapy

No adjuvant chemotherapy

147

86

0.34 (0.24 - 0.50)

< 0.001

0.50 (0.34 - 0.74)

0.001

Number of nodes examined < 12

Number of nodes examined ≥ 12

60

173

1.30 (0.89 - 1.90)

0.17

Number of comorbidities ≤ 1

Number of comorbidities > 1

179

54

0.55 (0.38 - 0.81)

0.002

0.76 (0.51 - 1.12)

0.16