Variable

Site of tumor

P-value

Right colon

Left colon

N

%

N

%

First-line chemotherapy regimens (n = 77 (right colon), n = 78 (left colon))

FOLFOX

54

70.10

47

60.30

CapeOX

12

15.60

10

12.80

FOLFIRI

4

5.20

18

23.10

Capecitabine

5

6.50

2

2.60

XELIRI

0

0.00

1

1.30

Etoposide/Cisplatin

2

2.60

0

0.00

Response to first-line chemotherapy (n = 77 (right colon), n = 78 (left colon))

Complete response

44

57.10

30

38.50

<0.001

Partial response

1

1.30

2

2.60

Stable disease

8

10.40

13

16.70

Progression

24

31.20

33

42.30

Second-line chemotherapy regimens (n = 41 (right colon), n = 42 (left colon))

FOLFOX

2

4.90

10

23.80

CapeOX

0

0.00

1

2.40

FOLFIRI

31

75.60

24

57.10

FOLFOXIRI

1

2.40

0

0.00

Capecitabine

3

7.30

3

7.10

Irinotecan

2

4.90

1

2.40

XELIRI

1

2.40

1

2.40

IROX

1

2.40

2

4.80

Response to second-line chemotherapy (n = 41 (right colon), n = 42 (left colon))

Complete response

2

4.90

1

2.40

0.159

Stable disease

4

9.80

4

9.50

Progression

35

85.40

37

88.10

Third-line chemotherapy regimens (n = 14 (right colon), n = 17 (left colon))

Capecitabine

0

0.00

2

11.80

FOLFIRI

1

7.10

2

11.80

FOLFOXIRI

1

7.10

1

5.90

Irinotecan

12

85.70

10

58.80

IROX

0

0.00

2

11.80

Response to third-line chemotherapy (n = 14 (right colon), n = 17 (left colon))

Progression

14

100.00

17

100.00

0.548

Chemotherapy-induced hematological toxicity (grade ≥ 3)

Anemia

13

16.90

17

21.80

0.254

Neutropenia

10

13.00

9

11.50

None or toxicity grade < 3

54

70.10

52

66.70

Chemotherapy-induced non-hematological toxicity (grade ≥ 3)

Oral mucositis

12

15.60

12

15.40

0.105

Diarrhea

9

11.70

6

7.70

Vomiting

13

16.90

6

7.70

Peripheral neuropathy

8

10.40

7

9.00

None or toxicity grade < 3

35

45.50

47

60.30