Variable | Site of tumor | P-value | ||||
Right colon | Left colon | |||||
N | % | N | % | |||
First-line chemotherapy regimens (n = 77 (right colon), n = 78 (left colon)) | FOLFOX | 54 | 70.10 | 47 | 60.30 |
|
CapeOX | 12 | 15.60 | 10 | 12.80 | ||
FOLFIRI | 4 | 5.20 | 18 | 23.10 | ||
Capecitabine | 5 | 6.50 | 2 | 2.60 | ||
XELIRI | 0 | 0.00 | 1 | 1.30 | ||
Etoposide/Cisplatin | 2 | 2.60 | 0 | 0.00 | ||
Response to first-line chemotherapy (n = 77 (right colon), n = 78 (left colon)) | Complete response | 44 | 57.10 | 30 | 38.50 | <0.001 |
Partial response | 1 | 1.30 | 2 | 2.60 | ||
Stable disease | 8 | 10.40 | 13 | 16.70 | ||
Progression | 24 | 31.20 | 33 | 42.30 | ||
Second-line chemotherapy regimens (n = 41 (right colon), n = 42 (left colon)) | FOLFOX | 2 | 4.90 | 10 | 23.80 |
|
CapeOX | 0 | 0.00 | 1 | 2.40 | ||
FOLFIRI | 31 | 75.60 | 24 | 57.10 | ||
FOLFOXIRI | 1 | 2.40 | 0 | 0.00 | ||
Capecitabine | 3 | 7.30 | 3 | 7.10 | ||
Irinotecan | 2 | 4.90 | 1 | 2.40 | ||
XELIRI | 1 | 2.40 | 1 | 2.40 | ||
IROX | 1 | 2.40 | 2 | 4.80 | ||
Response to second-line chemotherapy (n = 41 (right colon), n = 42 (left colon)) | Complete response | 2 | 4.90 | 1 | 2.40 | 0.159 |
Stable disease | 4 | 9.80 | 4 | 9.50 | ||
Progression | 35 | 85.40 | 37 | 88.10 | ||
Third-line chemotherapy regimens (n = 14 (right colon), n = 17 (left colon)) | Capecitabine | 0 | 0.00 | 2 | 11.80 |
|
FOLFIRI | 1 | 7.10 | 2 | 11.80 | ||
FOLFOXIRI | 1 | 7.10 | 1 | 5.90 | ||
Irinotecan | 12 | 85.70 | 10 | 58.80 | ||
IROX | 0 | 0.00 | 2 | 11.80 | ||
Response to third-line chemotherapy (n = 14 (right colon), n = 17 (left colon)) | Progression | 14 | 100.00 | 17 | 100.00 | 0.548 |
Chemotherapy-induced hematological toxicity (grade ≥ 3) | Anemia | 13 | 16.90 | 17 | 21.80 | 0.254 |
Neutropenia | 10 | 13.00 | 9 | 11.50 | ||
None or toxicity grade < 3 | 54 | 70.10 | 52 | 66.70 | ||
Chemotherapy-induced non-hematological toxicity (grade ≥ 3) | Oral mucositis | 12 | 15.60 | 12 | 15.40 | 0.105 |
Diarrhea | 9 | 11.70 | 6 | 7.70 | ||
Vomiting | 13 | 16.90 | 6 | 7.70 | ||
Peripheral neuropathy | 8 | 10.40 | 7 | 9.00 | ||
None or toxicity grade < 3 | 35 | 45.50 | 47 | 60.30 |