Scales

Mean at start

p (mean difference at start)

Mean at 6 months

p (mean difference within groups)

Effect size within groups

OVGI

PGI

OVGI/PGI

OVGf

PGf

OVGI/OVGf

PGI/PGf

OVGI/OVGf

PGI/PGf

Functional scale

Overall well-being

62

63

0.987

71.7

71.6

0.002

0.001

0.9

0.7

Physical function

87.1

85.3

0.649

89.6

91

0.356

0.047

0.2

0.4

Daily activity

70.6

70.2

0.301

76.7

81.8

0.155

0.001

0.3

0.7

Emotional well-being

43.9

51.5

0.716

64.4

66.9

0.003

0.005

0.7

0.6

Cognitive function

67.8

63.6

0.339

67.2

60.9

0.921

0.64

0

−0.1

Social function

48.9

55.6

0.724

64.4

62

0.009

0.223

0.6

0.3

Symptoms

Fatigue

31.9

28.6

0.692

20.4

18.4

0.023

0.032

−0.6

−0.5

Nausea

6.7

7.6

0.332

8.3

3.6

0.739

0.274

0.1

−0.3

Pain

34.4

33.3

0.653

13.3

10.9

<0.001

<0.001

−1.1

−1.1

Dysnea

5.6

4.0

0.218

2.2

6.3

0.264

0.325

−0.3

0.1

Insomnia

43.3

35.4

0.338

36.7

30.2

0.281

0.262

−0.2

−0.2

Anorexia

25.6

28.3

0.205

17.8

9.4

0.293

0.002

−0.3

−0.8

Constipation

33.3

32.3

0.357

40

32.3

0.339

0.874

0.2

0

Diarrhoea

5.6

4.0

0.365

5.6

9.4

1,000

0.169

0.0

0.4

Economic impact

51.1

45.5

0.778

35.6

37.5

0.011

0.133

−0.6

−0.3