|
| FOLFOX 4,6 | Capcitabine | XELOX | DeGramont | Test value* | p-value | Sig. | |||||
| No. | % | No | % | No. | % | No. | % | |||||
| Neurological toxicity | No | 8 | 16.0% | 7 | 87.5% | 2 | 16.7% | 2 | 100% | 25.861 | 0.000 | HS |
| G3,4 | 5 | 10.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 37 | 74.0% | 1 | 12.5% | 10 | 83.3% | 0 | 0.0% | ||||
| Anemia | No | 30 | 60.0% | 7 | 87.5% | 8 | 66.7% | 2 | 100% | 3.922 | 0.687 | NS |
| G3,4 | 2 | 4.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 18 | 36.0% | 1 | 12.5% | 4 | 33.3% | 0 | 0.0% | ||||
| Thrombocytopenia | No | 41 | 82.0% | 8 | 100% | 12 | 100% | 2 | 100% | 4.526 | 0.210 | NS |
| G3,4 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 9 | 18.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Neutropenia | No | 26 | 52.0% | 7 | 87.% | 9 | 75.0% | 1 | 50.0% | 8.575 | 0.199 | NS |
| G3,4 | 11 | 22.0% | 0 | 0.0% | 0 | 0.0% | 1 | 50.0% | ||||
| G1,2 | 13 | 26.0% | 1 | 12.5% | 3 | 25.0% | 0 | 0.0% | ||||
| Dermatological toxicity | No | 48 | 96.0% | 3 | 37.5% | 12 | 100% | 2 | 100% | 29.756 | 0.000 | HS |
| G3,4 | 0 | 0.0% | 1 | 12.5% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 2 | 4.0% | 4 | 50.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Nausea | No | 38 | 76.0% | 6 | 75.0% | 5 | 41.7% | 1 | 50.0% | 6.953 | 0.325 | NS |
| G3,4 | 1 | 2.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 11 | 22.0% | 2 | 25.0% | 7 | 58.3% | 1 | 50.0% | ||||
| Vomiting | No | 37 | 74.0% | 5 | 62.5% | 9 | 75.0% | 1 | 50.0% | 0.994 | 0.803 | NS |
| G3,4 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 13 | 26.0% | 3 | 37.5% | 3 | 25.0% | 1 | 50.0% | ||||
| Diarrhea | No | 21 | 42.0% | 4 | 50.0% | 8 | 66.7% | 1 | 50.0% | 3.401 | 0.757 | NS |
| G3,4 | 4 | 8.0% | 1 | 12.5% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 25 | 50.0% | 3 | 37.5% | 4 | 33.3% | 1 | 50.0% | ||||
| Allergy | No | 49 | 98.0% | 8 | 100% | 12 | 100% | 2 | 100% | 0.446 | 0.931 | NS |
| G3,4 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 1 | 2.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Hepatic toxicity | No | 43 | 86.0% | 6 | 75.0% | 9 | 75.0% | 1 | 50.0% | 2.587 | 0.460 | NS |
| G3,4 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 7 | 14.0% | 2 | 25.0% | 3 | 25.0% | 1 | 50.0% | ||||
| Renal toxicity | No | 46 | 92.0% | 8 | 100% | 12 | 100% | 2 | 100% | 1.864 | 0.601 | NS |
| G3,4 | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 4 | 8.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Oral mucositis | No | 35 | 70.0% | 8 | 100% | 10 | 83.3% | 2 | 100% | 5.082 | 0.533 | NS |
| G3,4 | 4 | 8.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 11 | 22.0% | 0 | 0.0% | 2 | 16.7% | 0 | 0.0% | ||||
| Fatigue | No | 39 | 78.0% | 7 | 87.5% | 9 | 75.0% | 2 | 100% | 4.355 | 0.629 | NS |
| G3,4 | 2 | 4.0% | 1 | 12.5% | 0 | 0.0% | 0 | 0.0% | ||||
| G1,2 | 9 | 18.0% | 0 | 0.0% | 3 | 25.0% | 0 | 0.0% | ||||
| Others | Headache | 1 | 2.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 10.340 | 0.324 | NS |
| Thrombophlebitis | 5 | 10.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Abdominal cramp | 5 | 10.0% | 0 | 0.0% | 0 | 0.0% | 1 | 50.0% | ||||
| Phlebitis | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||
| Abdominal pain | 2 | 4.0% | 0 | 0.0% | 0 | 0.0% | 0 | 0.0% | ||||