Age < 50

Age ≥ 50

Test value*

p-value

Sig.

No.

%

No.

%

Neurological toxicity

No

12

40.0%

7

16.7%

7.525

0.023

S

G3,4

0

0.0%

5

11.9%

G1,2

18

60.0%

30

71.4%

Anemia

No

20

66.7%

27

64.3%

0.133

0.936

NS

G3,4

1

3.3%

1

2.4%

G1,2

9

30.0%

14

33.3%

Thrombocytopenia

No

27

90.0%

36

85.7%

0.294

0.588

NS

G3,4

0

0.0%

0

0.0%

G1,2

3

10.0%

6

14.3%

Neutropenia

No

21

70.0%

22

52.4%

3.210

0.201

NS

G3,4

5

16.7%

7

16.7%

G1,2

4

13.3%

13

31.0%

Dermatological toxicity

No

25

83.3%

40

95.2%

3.218

0.200

NS

G3,4

1

3.3%

0

0.0%

G1,2

4

13.3%

2

4.8%

Nausea

No

23

76.7%

27

64.3%

1.701

0.427

NS

G3,4

0

0.0%

1

2.4%

G1,2

7

23.3%

14

33.3%

Vomiting

No

22

73.3%

30

71.4%

0.032

0.859

NS

G3,4

0

0.0%

0

0.0%

G1,2

8

26.7%

12

28.6%

Diarhea

No

14

46.7%

20

47.6%

0.765

0.682

NS

G3,4

3

10.0%

2

4.8%

G1,2

13

43.3%

20

47.6%

Allergy

No

29

96.7%

42

100.0%

1.420

0.233

NS

G3,4

0

0.0%

0

0.0%

G1,2

1

3.3%

0

0.0%

Hepatic toxicity

No

22

73.3%

37

88.1%

2.577

0.108

NS

G3,4

0

0.0%

0

0.0%

G1,2

8

26.7%

5

11.9%

Renal toxicity

No

28

93.3%

40

95.2%

0.121

0.728

NS

G3,4

0

0.0%

0

0.0%

G1,2

2

6.7%

2

4.8%

Oral mucositis

No

26

86.7%

29

69.0%

3.017

0.221

NS

G3,4

1

3.3%

3

7.1%

G1,2

3

10.0%

10

23.8%

Fatigue

No

28

93.3%

29

69.0%

6.532

0.038

S

G3,4

0

0.0%

3

7.1%

G1,2

2

6.7%

10

23.8%

Others

Headache

1

3.3%

0

0.0%

3.384

0.336

NS

Thrombophlebitis

2

6.7%

3

7.1%

Abdominal cramp

1

3.3%

5

11.9%

Phlebitis

0

0.0%

0

0.0%

Abdominal pain

0

0.0%

2

4.8%