No. of assessed patients

Cycle 1

Cycle 2

Cycle 3

37

30

29

Events

Number (%)

Number (%)

Number (%)

P-value

Any Grade III & IV toxicity

17 (49.5%)

6 (20%)

4 (13.8%)

0.007

Diarrhea

8 (21.6%)

4 (13.3%)

2 (6.9%)

0.236

Mucositis

9 (24.3%)

3 (10%)

1 (3.4%)

0.038

Myelosuppression

12 (32.4%)

2 (6.7%)

3 (10.3%)

0.01

Neuropathy

2 (5.4%)

1 (3.3%)

1 (3.4%)

0.89

Nausea & Vomiting

2 (5.4%)

2 (6.7%)

0 (0.0%)

0.392

Treatment related mortality*

7 (18.9%)

1 (3.3%)

0 (0.0%)

0.01