| 5-FU adjustment [9] | |
| AUC (mg/h/L) | Dose adjustment |
| ≥45 | Reduce by 30% |
| 42 - 44 | Reduce by 25% |
| 39 - 41 | Reduce by 20% |
| 36 - 38 | Reduce by 10% |
| 25 - 35 | NO CHANGE NEEDED |
| 22 - 24 | Increase by 10% |
| 19 - 21 | Increase by 20% |
| 16 - 18 | Increase by 25% |
| 8 - 15 | Increase by 30% |
| Docetaxel adjustment [10] | |
| AUC (mg/h/L) | Dose adjustment |
| >5.5 | Reduce by 25% |
| 4.5 - 5.5 | Reduce by 10% |
| 3.5 - 4.5 | NO CHANGE NEEDED |
| 1.5 - 3.5 | Increase by 10% |
| <1.5 | Increase by 25% |