Study Enrollment (44 patients)

Cohort 1 (50 mg/m²), n = 3

Cohort 5 (219 mg/m²), n = 10

Cohort 2 (75 mg/m²), n = 3

Cohort 6 (285 mg/m²), n = 3

Cohort 3 (112.5 mg/m²), n = 4

Cohort 7 (427 mg/m²), n = 8

Cohort 4 (146 mg/m²), n = 4

Cohort 8 (555 mg/m²), n = 9

Characteristics

N

N (%)

Age (years old)

44

Median

57.7

18 to 64

31 (70.5)

65+

13 (29.5)

Sex

44

Male

23 (52.3)

Female

21 (47.7)

Ethnic Origin

44

White

43 (97.7)

Hispanic or Latino

1 (2.3)

Performance Status

44

0

10 (22.7)

1

29 (65.9)

2

5 (11.4)