TOXICITY

NUMBER (PERCENTAGE)

LIVER COMPLICATIONS

28 (29.8%)

Liver failure (ascites and/or grade I-II encephalopathy)

16

Upper bleeding by esophageal/fundic varices

7

Upper bleeding by portal hipertensive gastropathy

2

Hemoperitoneum

2

Grade IV hepatic encephalopathy

1

CARDIOVASCULAR

25 (26.6%)

Stroke (ischemic/hemorrhagic)

5/1

Distal vascular ischemia

6

Uncontrollable arterial hypertension

3

Cardiac arrhythmia

3

Cardiac ischemia

2

Sudden death

2

Cardiac failure

1

SKIN

14 (14.9%)

Hand-foot syndrome grade III/IV

12

Febrile generalized exfoliative dermatitis

1

Pustular psoriasis

1

INFECTIONS

14 (14.9%)

Pneumonia

5

Cholecystitis

2

Liver abscess

2

Appendicitis

1

Other

4

PAIN

8 (8.5%)

UPPER BLEEDING DUE TO GASTRIC/ESOPHAGEAL ULCER

4 (4.3%)

HYPOGLYCEMIC COMA

1 (1.1%)

TOTAL

94