Time

Treatment group

Control group

t

P

Day 1 of treatment

5.45 ± 1.30*

6.95 ± 1.23

−6.14

0.0123

The 5th day of treatment

3.05 ± 1.77*

4.15 ± 1.86

−3.25

0.0029

Day 7 of treatment

1.88 ± 1.67*

3.01 ± 1.29

−2.22

0.0000