Time

Treatment group

Control group

t

P

Day 1 of treatment

5.90 ± 0.92*

6.83 ± 1.01

−6.17

0.0105

The 5th day of treatment

2.76 ± 0.93*

4.59 ± 1.08

−3.39

0.0002

Day 7 of treatment

1.64 ± 0.45*

2.83 ± 0.38

−2.21

0.0008