Variable

Definitions

$x_1\left(0\right)$

Initial healthy B cells

$x_2\left(0\right)$

Initial healthy progenitor cells

$x_3\left(0\right)$

Initial HHV-8 specific effector cells

$x_4\left(0\right)$

Initial infected B cells

$x_5\left(0\right)$

Initial infected progenitor cells

$x_6\left(0\right)$

Initial HHV-8 viral concentration

$x_7\left(0\right)$

Initial KS cells

Parameter

Definitions

$S_1$

Source of healthy B cells

$S_2$

Source of healthy progenitor cells

${\mu }_1$

Death rate constant of healthy B cells

${\mu }_2$

Death rate constant of healthy progenitor cells

${\mu }_3$

Death rate constant of HHV-8 effector cells

${\mu }_4$

Lytic death rate of infected B cells due to burst of HHV-8

${\mu }_5$

Removal rate of KS cells

${\widehat{\mu }}_5$

KS progression rate constant

${\mu }_6$

Death rate constant of HHV-8 virions

${\mu }_7$

Death rate constant of KS cells

${\beta }_1$

Infection rate constant of healthy B cells

${\beta }_2$

Killing rate constant of infected B cells

${\beta }_3$

Infection rate constant of healthy progenitor cells

${\beta }_4$

Killing rate constant of infected progenitor cells

r

Proliferation rate of HHV-8 specific CD8 T cells

N

Burst size of HHV-8