Parameter

Group

SOD (u/ml)

Nitric oxide (µmol/l)

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Mean ± S.E.

(Ta) significant test

(Tb) significant test

Control

13.13 ± 0.908

-

0.000^*

20.58 ± 0.849

-

0.090

DOX

4.74 ± 0.423

0.000^*

-

11.50 ± 1.696

0.002^*

-

DOX pretreated with grape seed extract (GSPE)

10.33 ± 1.137

0.017^*

0.000^*

12.55 ± 1.875

0.005^*

0.000^*

DOX pretreated with Vitamin E

13.25 ± 0.495

0.920

0.000^*

25.34 ± 2.75

0.090

0.000^*

DOX pretreated with grape seed extract (GSPE) combined with Vitamin E

16.54 ± 0.484

0.005^*

0.000^*

19.54 ± 0.825

0.693

0.027^*