| HIV Protein | Functions in Virus Lifecycle | Host Cell Kinase Interactions |
| Nef | - Downregulates CD4 receptor expression - NF-κB Activation - T-Cell Activation - Increase Tat expression | - CCNK - HCK - PAK1 |
| Tat | - NF-κB dependent HIV-1 LTR activation - Necessary for Replication | - RAF 1 |
| Vif | - Replication in Lymphocytes and Macrophages - Inactivation of cytidine deaminases | - HCK |