Polydrug use†

Ever used

45 (87%)

37 (67%)

0.02

Recent use

8 (18%)1

3 (8%)2

0.20

Composite neuropsychological test z-scores

Learning and memory

−0.26± 1.033

0.09 ± 0.99

0.09

Executive function

0.15 ± 0.99

0.21 ± 1.17

0.77

Working memory

−0.14 ± 0.78

0.29 ± 0.89

0.01

Psychomotor speed

0.28 ± 0.62

0.27 ± 0.84

0.96

Global

−0.07 ± 0.564

0.13 ± 0.62

0.11

Beck Depression Inventory (BDI) scores

Somatic subscore, median (Q1 - Q3)

4.0 (2.5 - 6.5)

2.0 (0 - 3.0)5

<0.000

Cognitive-affective subscore, median (Q1 - Q3)

5.0 (1.5 - 9.0)

1.0 (0 - 4.0)5

0.001

Total score, median (Q1 - Q 3)

10.0 (5.0 - 15.0)

4.0 (1.0 - 7.0)5

<0.000