A. Units recorded from all animals | |||||||||||||||||||
Dose: |
| Acute Day 1 | Baseline Day 10 | Rechallenge Day 10 | |||||||||||||||
N |
| ↑ |
| ↓ | ≠ |
| ↑ |
| ↓ |
| ≠ |
| ↑ |
| ↓ | ≠ | |||
saline | 45 | 2 | (4%) | 3 | (7%) | 40 (89%) | 0 | (0%) | 2 | (4%) | 43 | (96%) | 1 | (2%) | 3 | (7%) | 41 (91%) | ||
0.6 mg/kg MPD | 147 | 32 | (20%) | 21 | (14%) | 94 (64%) | 31 | (21%) | 31 | (21%) | 85 | (58%) | 52 | (36%) | 18 | (12%) | 77 (52%) | ||
2.5 mg/kg MPD | 165 | 69 | (42%) | 35 | (21%) | 61 (37%) | 82 | (50%) | 23 | (14%) | 60 | (86%) | 93 | (56%) | 22 | (13%) | 50 (31%) | ||
10.0 mg/kg MPD | 102 | 61 | (60%) | 18 | (18%) | 23 (22%) | 69 | (68%) | 16 | (17%) | 17 | (15%) | 63 | (62%) | 20 | (20%) | 19 (18%) | ||
|
| B. Units recorded from behaviorally sensitized animals |
| ||||||||||||||||
Dose: | N | Acute Day 1 | Baseline Day 10 | Rechallenge Day 10 | |||||||||||||||
| ↑ |
| ↓ | ≠ |
| ↑ |
| ↓ |
| ≠ |
| ↑ |
| ↓ | ≠ | ||||
0.6 mg/kg MPD | 62 | 20 | (32%) | 19 | (31%) | 23 (37%) | 37 | (60%) | 14 | (23%) | 11 | (17%) | 14 | (23%) | 38 | (61%) | 10 (16%) | ||
2.5 mg/kg MPD | 103 | 16 | (16%) | 52 | (50%) | 35 (34%) | 24 | (23%) | 53 | (52%) | 26 | (25%) | 22 | (21%) | 71 | (69%) | 10 (10%) | ||
10.0 mg/kg MPD | 74 | 15 | (20%) | 47 | (64%) | 12 (16%) | 8 (11%) | 61 | (82%) | 5 | (7%) | 10 | (13%) | 53 | (72%) | 11 (15%) | |||
| C. Units recorded from behaviorally tolerant animals |
| |||||||||||||||||
| Acute Day 1 | Baseline Day 10 | Rechallenge Day 10 | ||||||||||||||||
Dose: | N |
| ↑ |
| ↓ | ≠ |
| ↑ |
| ↓ |
| ≠ |
| ↑ |
| ↓ | ≠ | ||
0.6 mg/kg MPD | 85 | 8 | (9%) | 17 | (20%) | 60 (71%) | 6 | (7%) | 13 | (15%) | 66 | (78%) | 19 | (22%) | 4 | (5%) | 62 (73%) | ||
2.5 mg/kg MPD | 62 | 25 | (40%) | 14 | (23%) | 23 (37%) | 33 | (53%) | 6 (10%) | 23 | (37%) | 39 | (63%) | 6 (10%) | 17 (27%) | ||||
10.0 mg/kg MPD | 28 | 15 | (54%) | 9 (32%) | 4 (14%) | 15 | (54%) | 7 (25%) | 6 | (21%) | 15 | (54%) | 5 (18%) | 8 (28%) | |||||