| Circulation time (min) | The concentration of sinomenine (mg/mL) | Extraction ratio (%) | |
| Extract | Raffinate | ||
| 5 | / | 0.17 | 95.8 |
| 10 | / | 0.16 | 96.0 |
| 15 | / | 0.18 | 95.5 |
| 20 | / | 0.16 | 96.0 |
| 30 | 15.32 | 0.15 | 96.2 |