| Type of nanobiosensor | Samples | Advantages |
| Mechanical | Nanocantilever, acoustic biosensors | Highly mass sensitive, more the size decreases, more the mass reduces |
| Optical | Surface plasmon resonance (SPR), LSPR, FRET, SERS, evanescent field based devices, photonic crystal devices | Extremely sensitive, small volumes required, remarkable optical properties |
| Nanowire | Boron-doped silicon nanowires (SiNWs) | Analyte independent, sensitive, real time and quantitative fashion, biological and chemical species can be used. |
| Electronic | Lab on a chip | Each chip contains multiple sensors, hence different target DNA molecules can be addressed |
| PEBBLE | Poly (decyl methacrylate)-based fluorescent PEBBLE | Monitoring inter and intracellular ions and molecules in real time, high reversibility and stability to leaching and photo bleaching. |
| Nanoshell | Gold nanoshells | Rapid assays, enhance chemical sensing |
| Enzyme-based | 4-Hydroxyphenylpyruvate Dioxygenase Enzyme | Precise and low cost techniques |