Parameter

WThE

Placebo

Delta change

p-value¹

Baseline

4 weeks

Baseline

4 weeks

WThE

Placebo

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Gastrointestinal symptoms

Stagnant gas/bloated abdomen

1.84

1.31 - 2.36

0.99

0.60 - 1.38

1.81

1.41 - 2.21

1.10

0.85 - 1.36

−0.84

−1.30; −0.39

−0.71

−1.05; −0.36

0.6091

Gas leakage/flatulence

1.78

1.26 - 2.30

1.13

0.81 - 1.46

1.79

1.36 - 2.23

1.27

0.87 - 1.66

−0.65

−1.03; −0.26

−0.53

−0.86; −0.19

0.0946^t

Feeling of fullness/tightness due to constipation

1.56

0.98 - 2.14

0.78

0.41 - 1.14

1.76

1.37 - 2.15

1.28

0.91 - 1.65

−0.79

−1.20; −0.37

−0.48

−0.84; −0.13

0.2503

Grumbling in the gastrointestinal tract

1.43

0.92 - 1.94

0.69

0.33 - 1.04

1.10

0.66 - 1.53

0.72

0.42 - 1.03

−0.75

−1.20; −0.29

−0.37

−0.74; 0.00

0.1851

Abdominal discomfort/pain

0.98

0.58 - 1.39

0.39

0.09 - 0.69

1.12

0.78 - 1.46

0.69

0.34 - 1.05

−0.60

−0.98; −0.21

−0.43

−0.75; −0.10

0.4849

Mean gastrointestinal score

1.52

1.07 - 1.97

0.80

0.52 - 1.07

1.52

1.18 - 1.85

1.01

0.75 - 1.28

−0.72

−1.09; −0.36

−0.50

−0.76; −0.25

0.2972

Feeling of incomplete emptying

1.61

1.05 - 2.17

1.12

0.67 - 1.58

1.59

1.18 - 1.99

1.17

0.85 - 1.50

−0.48

−0.87; −0.10

−0.41

−0.79; −0.04

0.8816

GSRS questionnaire

Diarrhea

1.54

1.18 - 1.91

1.41

1.06 - 1.76

1.51

1.22 - 1.80

1.68

1.33 - 2.03

−0.14

−0.51; −0.24

0.18

−0.16; −0.52

0.1199

Indigestion

3.34

2.74 - 3.94

2.56

2.23 - 2.90

3.43

2.93 - 3.93

2.98

2.59 - 3.36

−0.77

−1.28; 0.27

−0.45

−0.92; −0.01

0.3246

Constipation

3.04

2.38 - 3.70

2.13

1.76 - 2.49

3.56

3.08 - 4.04

2.86

2.35 - 3.37

−0.91

−1.37; −0.45

−0.70

−1.15; −0.25

0.4917

Abdominal pain

2.53

2.10 - 2.96

1.74

1.47 - 2.00

2.47

2.08 - 2.87

2.10

1.76 - 2.44

−0.79

−1.16; −0.43

−0.37

−0.71; −0.03

0.0834^t

Reflux

1.87

1.37 - 2.36

1.34

1.10 - 1.58

1.76

1.32 - 2.20

1.64

1.23 - 2.06

−0.53

−0.96; −0.10

−0.12

−0.44; −0.20

0.1591

Total score

12.29

10.54 - 14.04

9.15

8.38 - 9.92

12.71

11.08 - 14.35

11.24

9.83 - 12.65

−3.15

−4.43; −1.87

−1.48

−2.77; −0.18

0.0607^t