Parameter

WThE

Placebo

Delta change

p-value¹

Baseline

4 weeks

Baseline

4 weeks

WThE

Placebo

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Mean

95% CI

Stool frequency

Overall

3.64

3.21 - 4.07

4.61

3.91 - 5.30

3.43

2.92 - 3.93

4.24

3.77 - 4.71

0.96

0.53 - 1.40

0.81

0.41 - 1.21

0.5907

Males

3.70

2.02 - 5.38

5.20

3.02 - 7.38

4.00

2.61 - 5.39

4.00

2.84 - 5.16

1.50

0.74 - 2.26

0.00

−0.62 - 0.62

0.0141*

Females

3.62

3.20 - 4.05

4.39

3.62 - 5.16

3.25

2.67 - 3.83

4.31

3.74 - 4.89

0.77

0.24 - 1.31

1.06

0.62 - 1.51

0.3734

Baseline stool frequency > median

4.53

4.20 - 4.85

5.88

4.91 - 6.84

4.69

4.31 - 5.07

4.94

4.59 - 5.29

1.35

0.61 - 2.09

0.25

−0.14 - 0.64

0.0126*

Baseline stool frequency ≤ median

3.00

2.66 - 3.34

3.68

3.16 - 4.21

2.65

2.37 - 2.94

3.81

3.16 - 4.46

0.68

0.11 - 1.25

1.15

0.60 - 1.71

0.2076

Stool consistency

Overall

3.52

3.12 - 3.93

3.44

3.09 - 3.78

2.88

2.58 - 3.17

3.03

2.69 - 3.38

−0.09

−0.47 - 0.29

0.16

−0.22 - 0.53

0.3456