CAR | Factor | TCR |
Single chain | Composition | Heterodimer |
Surface antigen | Target | Peptide complex |
Higher | Receptor affinity | Lower |
Shorter (less than 2 min) | Required time to start immune response | Longer (5 to 10 min) |
Linked (2nd and 3rd generation) | Costimulation | Separated |
Disorganized | Formation of immune synaps | Systematic bull’s eye structure |
100 or less | Required number of Ag to recognize | 1 |
Yes | Coreceptor | Yes |
Yes | Serial Killing | Yes |