Group

Sample size

IVP

Active ingredient(s)

Dose rate

2

8

NexGard®

(IVP 1)

Afoxolaner

(2.27% w/w)

As close as possible to 2.5 mg Afoxolaner per kg, but not inferior

(minimum dose as per Table 2 below)

3

8

NexGard Spectra®

(IVP 2)

Afoxolaner (1.875% w/w)

and milbemycin oxime (0.375% w/w) [see Amendment 1]

As close as possible to 2.5 mg Afoxolaner per kg, but not inferior

[Note: Equivalent to 0.5 mg/kg Milbemycin oxime, but for the purpose of this study this active was not considered in dosing tables]

To be as close as to 2.5 mg/kg of afoxolaner, the following dosing chart was used:

Dog weight

Chewable tablet size (g)

Dose range of afoxolaner (mg/kg)

0.5

1.25

3

6*

Min

Max

≥2.00 kg to 4.50 kg

1

2.5

5.7

>4.50 kg to 9.00 kg

2

4.9

>9.00 kg to 11.30 kg

1

3.1

>11.30 kg to 13.50 kg

3

3.0

>13.50 kg to 15.80 kg

1

1

2.9

>15.80 kg to 18.00 kg

4

2.8