Group | Sample size | IVP | Active ingredient(s) | Dose rate | ||||||
2 | 8 | NexGard® (IVP 1) | Afoxolaner (2.27% w/w) | As close as possible to 2.5 mg Afoxolaner per kg, but not inferior (minimum dose as per Table 2 below) | ||||||
3 | 8 | NexGard Spectra® (IVP 2) | Afoxolaner (1.875% w/w) and milbemycin oxime (0.375% w/w) [see Amendment 1] | As close as possible to 2.5 mg Afoxolaner per kg, but not inferior [Note: Equivalent to 0.5 mg/kg Milbemycin oxime, but for the purpose of this study this active was not considered in dosing tables] | ||||||
To be as close as to 2.5 mg/kg of afoxolaner, the following dosing chart was used: | ||||||||||
Dog weight | Chewable tablet size (g) | Dose range of afoxolaner (mg/kg) | ||||||||
0.5 | 1.25 | 3 | 6* | Min | Max | |||||
≥2.00 kg to 4.50 kg | 1 |
|
|
| 2.5 | 5.7 | ||||
>4.50 kg to 9.00 kg | 2 |
|
|
| 4.9 | |||||
>9.00 kg to 11.30 kg |
| 1 |
|
| 3.1 | |||||
>11.30 kg to 13.50 kg | 3 |
|
|
| 3.0 | |||||
>13.50 kg to 15.80 kg | 1 | 1 |
|
|
| 2.9 | ||||
>15.80 kg to 18.00 kg | 4 |
|
|
| 2.8 | |||||