Day | Procedure |
−7 to −1 | Acclimation period |
−7 to 27* | Antimicrobial treatment |
−7 to 84 | Observed dogs daily for clinical normality Monitored environmental parameters in cage environment |
−7 | Clinical examinations Body weights Biopsies (food to be removed the afternoon prior to Day −7) |
−2 | Clinical examinations Photographic documentation Mite counts and clinical assessments Body weights |
−1 | Randomization |
0 | Appropriate treatment dose administration to Groups 2 and 3 (according to Day −2 weight) Specific post-administration health observation (hourly up to four hours after IVP administration) |
14 | Clinical examinations |
27 | Body weights Biopsies |
28 | Clinical examinations Photographic documentation Mite counts and clinical assessments Appropriate treatment dose administration to Groups 2 and 3 (according to Day 27 weight) Specific post-administration health observation (hourly up to four hours after IVP administration) |
42 | Clinical examinations |
55 | Body weights |
56 | Clinical examinations Photographic documentation Mite counts and clinical assessments Appropriate treatment dose administration to Groups 2 and 3 (according to Day 55 weight) Specific post-administration health observation (hourly up to four hours after IVP administration) |
70 | Clinical examinations |
84 | Body weights Clinical examinations Photographic documentation Mite counts and clinical assessments |