Day

Procedure

−7 to −1

Acclimation period

−7 to 27*

Antimicrobial treatment

−7 to 84

Observed dogs daily for clinical normality

Monitored environmental parameters in cage environment

−7

Clinical examinations

Body weights

Biopsies (food to be removed the afternoon prior to Day −7)

−2

Clinical examinations

Photographic documentation

Mite counts and clinical assessments

Body weights

−1

Randomization

0

Appropriate treatment dose administration to Groups 2 and 3 (according to Day −2 weight)

Specific post-administration health observation (hourly up to four hours after IVP administration)

14

Clinical examinations

27

Body weights

Biopsies

28

Clinical examinations

Photographic documentation

Mite counts and clinical assessments

Appropriate treatment dose administration to Groups 2 and 3 (according to Day 27 weight)

Specific post-administration health observation (hourly up to four hours after IVP administration)

42

Clinical examinations

55

Body weights

56

Clinical examinations

Photographic documentation

Mite counts and clinical assessments

Appropriate treatment dose administration to Groups 2 and 3 (according to Day 55 weight)

Specific post-administration health observation (hourly up to four hours after IVP administration)

70

Clinical examinations

84

Body weights

Clinical examinations

Photographic documentation

Mite counts and clinical assessments