Class

Relative weight loss

Side Effects

Therapeutic Considerations

Gastrointestinal lipase inhibitor: (orlistat)

↓

Loose stools, GI upset, rare liver failure

Oral medication, decreases fat absorption, may require vitamin supplementation

GLP-1 receptor agonist: (liraglutide 3.0 mg)

↓↓

Nausea, GI upset, rare gallstones and pancreatitis

Subcutaneous injectable, increases satiety