Clinical signs on diagnosis

n/N = 66

(%)

Anemia manifestations

Anemic syndrome

40

(60.6)

Hemolytic anemia

13

(19.7)

Anemic heart disease

7

(10.6)

Isolated conjunctiva pallor

5

(7.6)

GIT manifestations

Epigastric pain

30

(45.5)

glossitis

21

(31.8)

diarrhea

6

(9)

constipation

4

(6)

dysphagia

3

(4.5)

Dermatologic manifestations

melanodermia

36

(54.5)

Neuropsychiatric manifestations

polyneuropathy

27

(40.9)

posterior cord syndrom

1

(1.5)

Acute depression

1

(1.5)

Venous manifestations

Saphenous and femoral thrombophlebitis

1

(1.5)

Portal vein thrombosis incidentally discovered

1

(1.5)

Paraclinical signs

n/N

(%)

Anemia

65/66

(98.5)

Thrombocytoenia

33/66

(50)

Leukocytopenia

29/66

(43.9)

Pancytopenia

25/66

(37.9)

Bicytopenia

18/66

(27.3)

Thrombocytosis

2/66

(3)

Hyperleukocytosis

1/66

(1.5)

Vitamin B12 deficiency

59/66

(89.39)

Central megaloblastosis

37/47

(88.1)

Positive anti-intrinsic factor antibodies

50/51

(98.03)

Positive anti-parietal cells antibodies

25/36

(69.44)

Atrophic gastritis

34/37

(91.89)

Antrum and pyloric metaplasia

10/37

(27.02)

Helicobacter pylori

2/37

(5.4)