| Study | Protocol | Number | Line | Median progression-free survival (months) | Hazard ratio (95% confidence interval) | Median overall survival (months) | Hazard ratio (95% confidence interval) |
| ASPEN [19] | Everolimus vs Sunitinib | 57
51 | 1
1 | 5.6
8.3 | 1.41 (1.03 - 1.92) | 13.2
31.5 | 1.12 (0.7 - 2.1) |
| RECORD [20] | Everolimus vs Sunitinib | 31
35 | 1
1 | 7.9
10.7 | 1.4 (1.2- 1.8) | - | - |
| ESPN [21] | Everolimus vs Sunitinib | 35
33 | 1
1 | 4.1
6.1 | - | 14.9
16.2 | - |
| ARCC [22] | Interferon-α vs Temsirolimus | 36
37 | 1
1 | 1.8
7.0 | 0.38 (0.23 - 0.62) | 4.3
11.6 | 0.49 (0.29 - 0.85) |
| SWOG [23] | Tivantinib vs Tivantinib + erlotinib | 25
25 | 1 et 2
1 et 2 | 2
3.9 | - | 10.3
11.3 | - |