Adverse events

Raw relative risk (95% confidence interval)

DHPP

ASAQc

ASAQf

ASAQl

AQSP*

ASMQ

ASSP

Vomiting/nausea

1.00

(0.85 - 1.18)

-

1.45

(1.18 - 1.78)

1.24

(0.98 - 1.58)

1.12

(0.82 - 1.53)

0.80

(0.48 - 1.30)

2.54

(1.63 - 3.98)

Anaemia

2.23

(1.64 - 3.02)

1.70

(1.26 - 2.30)

4.18

(2.93 - 5.95)

1.53

(1.26 - 1.86)

0.91

(0.61 - 1.32)

0.85

(0.74 - 0.99)

-

Abdominal pain

1.10

(0.93 - 1.28)

1.63

(1.21 - 2.20)

2.02

(0.97 - 4.21)

1.25

(0.88 - 1.81)

1.10

(0.80 - 1.49)

-

1.07

(0.41 - 2.76)

Diarrhoea

0.85

(0.74 - 0.97)

0.74

(0.39 - 1.40)

0.94

(0.75 - 1.18)

0.71

(0.44 - 1.14)

0.93

(0.60 - 1.44)

-

-

Pruritus

0.77

(0.43 - 1.38)

1.63

(0.74 - 3.58)

10.67

(4.25 - 26.76)

5.94

(0.7 - 50.81)

3.56

(1.85 - 6.83)

-

-

Cough

0.91

(0.85 - 0.98)

1.27

(0.80 - 2.01)

0.91

(0.80 - 1.04)

0.62

(0.48 - 0.77)

-

-

-

Anorexia

0.89

(0.76 - 1.03)

2.19

(1.29 - 3.70)

0.98

(0.76 - 1.25)

1.55

(1.05 - 2.28)

1.95

(1.37 - 2.76)

-

-

Headache

0.80

(0.67 - 0.96)

1.09

(0.79 - 1.52)

-

-

0.60

(0.31 - 1.12)

0.53

(0.40 - 0.68)

2.38

(0.46 - 12.26)

Number of studies with AL

14

5

8

8

4

3

1

Number of children in AL

4740

1250

2471

909

540

711

634

Number of children in trt arm

3681

1226

2222

763

593

552

664