| Variable | All Patients (N = 295) n (%) | Non-High-Risk (n = 228) n (%) | *High-Risk (n = 67) n (%) | P value |
| Sex |
|
|
| 0.531 |
| Female | 153 (51.9) | 116 (50.9) | 37 (55.2) |
|
| Male | 142 (48.1) | 112 (49.1) | 30 (44.8) |
|
| Race |
|
|
|
|
| Black/African American | 66 (22.4) | 44 (19.3) | 22 (32.8) | 0.019 |
| White | 223 (75.6) | 179 (78.5) | 44 (65.7) | 0.123 |
| Comorbidity |
|
|
|
|
| AV block | 44 (14.9) | 33 (14.5) | 11 (16.4) | 0.695 |
| Chronic kidney disease | 182 (61.7) | 139 (61.0) | 43 (64.2) | 0.634 |
| Coronary artery disease | 132 (44.8) | 101 (44.3) | 31 (46.3) | 0.776 |
| Defibrillator | 11 (5.4) | 10 (4.4) | 6 (9.0) | 0.147 |
| Diabetes mellitus | 123 (41.7) | 93 (40.8) | 30 (44.8) | 0.561 |
| Hypertension | 258 (87.5) | 198 (86.8) | 60 (89.6) | 0.556 |
| Myocardial infarction | 68 (23.1) | 52 (22.4) | 17 (25.4) | 0.608 |
| Neuropathy | 136 (46.1) | 105 (46.1) | 31 (46.3) | 0.975 |
| Orthostatic hypotension | 45 (15.3) | 33 (14.5) | 12 (17.9) | 0.492 |
| Pacemaker | 47 (15.9) | 33 (14.5) | 14 (20.9) | 0.207 |
| Spinal stenosis | 87 (29.5) | 69 (30.3) | 18 (26.9) | 0.592 |
| Stroke | 50 (17.0) | 30 (13.2) | 20 (29.9) | 0.001 |
| Clinical Features |
|
|
|
|
| Diastolic dysfunction |
|
|
| 0.001 |
| None | 144/239 (60.3) | 132/175 (75.4) | 12/64 (18.8) |
|
| Grade 1 | 50/239 (20.9) | 23/175 (13.1) | 27/64 (42.2) |
|
| Grade 2 | 31/239 (13.0) | 15/175 (8.6) | 16/64 (25.0) |
|
| Grade 3 | 14/239 (5.9) | 5/175 (2.9) | 9/64 (14.1) |
|
| Low QRS voltage | 37/285 (13.0) | 27/218 (12.4) | 10/67 (14.9) | 0.589 |
| Q wave | 28/285 (9.8) | 21/218 (9.6) | 7/67 (10.5) | 0.845 |
| Right ventricular dysfunction |
|
|
| 0.001 |
| None | 222/264 (84.1) | 174/188 (87.9) | 48/66 (72.7) |
|
| Mild | 24/264 (9.1) | 15/198 (7.6) | 9/66 (13.6) |
|
| Moderate | 14/264 (5.3) | 5/198 (2.5) | 9/66 (13.6) |
|
| Severe | 4/264 (1.5) | 4/198 (2.0) | 0/66 (0) |
|
| Outcomes |
|
|
|
|
| ATTR-CA diagnosis | 6 (2.0) | 1 (0.4) | 5 (7.5) | 0.003 |
| Death | 85 (28.8) | 56 (24.6) | 29 (43.3) | 0.003 |