Mandatory diagnostic criteria in CAPS |
1. Clinical manifestations in different anatomical sites in less than 01 week |
2. Involvement of three or more organs or tissues |
3. Biopsy with histopathological analysis showing small vessel affection (stasis/thrombosis/angiogenesis) |
4. Laboratory changes with anti antiphospholipid antibodies - Anticardiolipin (AC) - Lupus anticoagulant (AL) - Anti-beta-2-glycoprotein I (anti B2-GPI) - Laboratory confirmation 12 weeks after the first collection |