Mandatory diagnostic criteria in CAPS

1. Clinical manifestations in different anatomical sites in less than 01 week

2. Involvement of three or more organs or tissues

3. Biopsy with histopathological analysis showing small vessel affection (stasis/thrombosis/angiogenesis)

4. Laboratory changes with anti antiphospholipid antibodies

- Anticardiolipin (AC)

- Lupus anticoagulant (AL)

- Anti-beta-2-glycoprotein I (anti B2-GPI)

- Laboratory confirmation 12 weeks after the first collection