Study

Agent

n

% exercise

p

(Category/Authors)

(Daily dose)

prolongation

1. Nitrates

Parker et al., 1995 [40]

Nitroglycerine (patches 0.4 mg/h for 12 hrs)

291

16

<0.001

Chrysant et al., 1993 [41]

Isosorbide-5-mononitrate (240 mg)

313

18

<0.01

2. β-blockers

Jamal et al., 1987 [42]

Carvedilol (50 mg)

12

24

<0.05

Schnellbacher et al., 1986 [43]

Bisoprolol: 10 mg

12

22

<0.05

20 mg

31

DiBianco et al., 1980 [44]

Acebutolol (1155 mg)

44

14

<0.01

Schwartz et al., 1981 [45]

Atenolol (100 - 200 mg)

12

32

<0.01

3. Calcium antagonists

Hung et al., 1983 [46]

Diltiazem (360 mg)

12

31

<0.05

Pine et al., 1982 [47]

Verapamil (240 - 480 mg)

18

42

<0.001

Andreasen et al., 1975 [48]

Verapamil (240 mg)

47

20

<0.05