Title

Origin

Methodology

Participants

Indication

Dose

Outcome

Intravenous MP pulse as treatment for hospitalized covid-19 critical patients: results of a randomized controlled trial4

Iran

Randomized Clinical Trial

68 TOTAL

34: MP intervention, 28: Standard, 06: deleted

Early pulmonary phase (Non-IOT Patients)

Methylprednisolone 250 mg (03 days)

Mortality rate was lower in the Methylprednisolone group (5.9% versus 42.9%; p < 0.001).

Efficacy of MP pulse therapy in patients with COVID-192

Russia

Retrospective Analysis

57

???

Methylprednisolone 500 mg (03 days)

Decrease in inflammatory tests. No patients transferred to the ICU.

Impact of Corticosteroids on Coronavirus Disease Results 201918

USA

Systematic Review

Review of 73 studies (21,350 patients). Database (PubMed, MEDLINE and EMBASE) of the literature published until July 22, 2020,

Critically ill patients under mechanical ventilation or in an ICU environment.

Varied

Corticosteroids showed benefit in critically ill patients.(OR, 0.65; 95% CI, 0.51 - 0.83; p = 0.0006). However, it was not possible to identify a greater benefit according to high or low dose regimens. The analysis was limited by highly heterogeneous literature for high-dose and low-dose corticosteroid regimens.

MP pulses in the second week improve prognosis in patients with severe coronavirus disease 2019 pneumonia: An observational comparative study using routine care data.19

Spain

Comparative observational study

242 patients with COVID-19 and elevation of inflammatory markers

From the 8th day

125 - 250 mg/d x3

The HR adjusted for death and death or IOT for patients in the MP group was 0.35 (95% CI 0.11 to 1.06, p = 0.064) and 0.33 (95% CI 0.13 to 0.84, p = 0.020), respectively. This difference was specifically seen in the subcohort of patients with spo2/fio2 ratio lower than 353 on the 7 day of disease.

High dose, short-term corticosteroids for ARDS caused by COVID-19: a number of cases.12

Japan

Case series

07

Critically ill patients under IOT

500 - 1000 mg/day (03 days) MP followed by 1 mg/kg in progressive reduction.

All patients extubated within 07 days.

The Effects of Steroids in Severe Hospitalized Patients with COVID-19: A Retrospective Cohort Study20.

China

retrospective, two-centred, cohort study

760 hospitalized. 659 patients were excluded because In total, 101 included: 39 in the steroid group and 63 in the non-steroid group

?

median dose of MP was 80 mg daily (40 - 160 mg daily), and 38 (90.5%) received methylprednisolone or equivalent < 150 mg. CTCD was initiated within 13 days (9 - 22 days)

short-term corticosteroids at low to moderate doses did not improve the clinical outcomes for patients with severe COVID-19.