N˚	Real Values of Factors					Cellulose Nanocrystal Isolation Yield
	Amount of Cellulose	Sulfuric Acid Concentration	Hydrolysis Time	Hydrolysis Temperature	Sonication Time	Experimental responses	Theoretical Responses	Residues
	X₁ (g)	X₂ (%. w/w)	X₃ (min)	X₄ (˚C)	X₅ (min)	Y_yield (%)	Y_yield (%)	r (%)
1	10	65	90	40	10	61.22	64.49	−3.27
2	10	40	10	80	10	96.26	93.22	3.04
3	7.5	52.5	126	60	20	51.39	57.93	−6.54
4	5	65	10	40	10	90.10	84.57	5.53
5	5	40	90	40	30	89.01	92.11	−3.10
6	10	65	10	40	10	84.17	87.03	−2.86
7	5	40	10	80	10	94.58	91.40	3.18
8	7.5	52.5	10	60	20	62.02	67.69	−5.67
9	7.5	52.5	50	60	20	57.78	59.76	−1.98
10	7.5	52.5	50	60	20	59.17	59.76	−0.59
11	10	40	90	40	30	96.27	91.47	4.80
12	7.5	52.5	50	60	20	54.02	59.76	−5.74
13	5	40	90	40	10	95.34	91.47	3.87
14	5	65	90	40	10	62.34	61.00	1.34
15	10	65	10	40	30	77.19	81.84	−4.65
16	5	65	10	80	30	15.81	15.60	0.21
17	10	40	10	40	30	97.01	95.45	1.56
18	12.2	52.5	50	60	20	67.12	63.83	3.29
19	10	40	90	80	30	82.81	87.62	−4.81
20	10	65	10	80	30	12.76	13.74	−0.98
21	5	65	90	80	10	5.85	0.75	5.10
22	7.5	76.2	50	60	20	3.52	5.14	−1.62
23	7.5	52.5	50	22	20	90.47	88.56	1.91
24	10	65	10	80	10	27.08	20.91	6.17
25	5	65	10	40	30	88.26	83.30	4.96
26	5	40	10	80	30	94.10	88.23	5.87
27	7.5	52.5	50	60	1	81.25	85.94	−4.69
28	5	40	90	80	10	92.21	90.02	2.19
29	5	40	10	40	10	97.04	98.31	−1.27
30	7.5	52.5	50	60	39	76.32	79.75	−3.43
31	10	40	90	40	10	96.14	94.74	1.40
32	5	65	90	40	30	59.64	61.55	−1.91
33	7.5	28.8	50	60	20	96.19	102.68	−6.49
34	10	40	10	80	30	85.00	86.14	−1.14
35	7.5	52.5	50	97.9	20	12.58	22.61	−10.03
36	7.5	52.5	50	60	20	66.81	59.76	7.05
37	10	65	90	80	10	2.48	3.83	−1.35
38	5	40	10	40	30	96.31	97.13	−0.82
39	10	65	90	40	30	61.31	61.13	0.18
40	10	65	90	80	30	3.25	−1.52	4.77
41	10	40	90	80	10	93.17	92.88	0.29
42	5	40	90	80	30	95.31	88.67	6.64
43	7.5	52.5	50	60	20	67.07	59.76	7.31
44	5	65	90	80	30	1.12	−0.69	1.81
45	5	65	10	80	10	13.78	18.86	−5.08
46	10	40	10	40	10	98.04	100.54	−2.50
47	7.5	52.5	50	60	20	69.19	59.76	9.43
48	2.8	52.5	50	60	20	51.09	62.50	−11.41