Residue Type

h-DHFR

Pyrimethamine

wt-DHFR

Pyrimethamine

dm-DHFR

Pyrimethamine

qm-DHFR

Pyrimethamine

pf-DHPS

Pyrimethamine

pf-TERT

Pyrimethamine

Hydrophobic

F31, I60, F34, L67, L22

I112, F58, L119, L46

F58, L40, L46

V195, L164, L46

R28

V351, L353, K214

Hydrogen Bonding

V115

Y170, I164

S111, G44

L40, A16, N54

I79, N25, Y159, S161

T393, I381, G395

Energy Kcal/mol

−7.9

−6.4

−6.8

−7.5

−6.6

−6.5

Artemisinin

Artemisinin

Artemisinin

Artemisinin

Artemisinin

Artemisinin

Hydrophobic

F34

F58, L46

L46

L46

Y80

A468, F465

Hydrogen Bonding

S59

S108

I112

/

Y80

/

Energy Kcal/mol

−9.4

−9.2

−8.5

−8.4

−8.3

−7.7