Residue Type | h-DHFR Pyrimethamine | wt-DHFR Pyrimethamine | dm-DHFR Pyrimethamine | qm-DHFR Pyrimethamine | pf-DHPS Pyrimethamine | pf-TERT Pyrimethamine |
Hydrophobic | F31, I60, F34, L67, L22 | I112, F58, L119, L46 | F58, L40, L46 | V195, L164, L46 | R28 | V351, L353, K214 |
Hydrogen Bonding | V115 | Y170, I164 | S111, G44 | L40, A16, N54 | I79, N25, Y159, S161 | T393, I381, G395 |
Energy Kcal/mol | −7.9 | −6.4 | −6.8 | −7.5 | −6.6 | −6.5 |
| Artemisinin | Artemisinin | Artemisinin | Artemisinin | Artemisinin | Artemisinin |
Hydrophobic | F34 | F58, L46 | L46 | L46 | Y80 | A468, F465 |
Hydrogen Bonding | S59 | S108 | I112 | / | Y80 | / |
Energy Kcal/mol | −9.4 | −9.2 | −8.5 | −8.4 | −8.3 | −7.7 |